NATURE WEBCAST – Tracing oncogene-driven remodeling of the intestinal stem cell niche

4 October 2021 | Engaging Online Event

Monday, October 4, 2021
7AM PDT | 10AM EDT | 3PM BST | 4PM CEST

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Interactions between tumor cells and the surrounding microenvironment contribute to tumor progression, metastasis and recurrence. This webcast will present an oncogene-associated, multicolor reporter mouse model, the Red2Onco system, that allows differential tracing of mutant and wild-type cells in the same tissue.

Applying this system to the small intestine revealed that oncogene-expressing mutant crypts alter the cellular organization of neighboring wild-type crypts, driving accelerated clonal drift in the intestinal epithelium. Comparative single-cell transcriptomic analysis of the Red2Onco system showed how environmental changes in the shared niche, mediated by direct and indirect signals from oncogene-expressing clones, promote the accelerated differentiation of wild-type stem cells, favoring tumorigenesis.Discover:

  • What happens if an oncogene is activated in a single intestinal stem cell?
  • How a single oncogenic stem cell influences its microenvironment?
  • Can we control this oncogene-driven remodeling effect?

Presenters

Presenter

Dr. Bon-Kyoung KooGroup Leader
Institute of Molecular Biotechnology of Austrian Academy of Sciences (IMBA)
Vienna, Austria
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Presenter

Dr. Jayshan CarpenModerator
Springer Nature
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